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William B. Castle
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William B. Castle

American physician

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study of intrinsic factor

  • In intrinsic factor

    …1920s by the American physician William B. Castle, whose research into the cause of pernicious anemia indicated that two substances were involved: one that is produced in the body (intrinsic) and the other—an extrinsic factor, later identified as vitamin B12—that is supplied in the diet.

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