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COMT inhibitor

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antiparkinson drugs

  • In antiparkinson drug: COMT and MAO-B inhibitors

    COMT inhibitors, such as tolcapone and entacapone, block the enzymatic breakdown of dopamine by the catechol-O-methyltransferase enzyme. These drugs commonly are given in conjunction with the combination of levodopa and carbidopa, since they inhibit COMT degradation of levodopa in peripheral tissues,…

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