Aging - Senescence, Lifestyle, Environment

aging

Table of Contents

Introduction
Biological theories of aging
- Genetic theories
- Nongenetic theories
  - Wear-and-tear theory
  - Cross-linking theory
  - Autoimmune theory
  - theory
  - Oxidative damage theory
  - Psychosociological theory
Natural history of aging
- Reproduction and aging
- Species differences in longevity and aging
- The inheritance of longevity
Senescence in mammals
- Changes in body composition, metabolism, and activity
- Changes in structural tissues
- Tissue cell loss and replacement
- Mammalian cell cultures
- Changes in tissue and cell morphology
Aging at the molecular and cellular levels
- Aging of genetic information systems
- Aging of the immune system
- Aging of neural and endocrine systems
Internal and external causes of aging
- External environmental agents
  - Ionizing radiation
  - Temperature
  - Physical wear of nonrenewable structures
  - Infectious disease and nutrition
- Internal environment: consequences of metabolism
Anti-aging and longevity research
- Antioxidants
- Calorie restriction and longevity
- Sirtuins
- Rapamycin
- Stem cells
- Genetics and life span

References & Edit History Quick Facts & Related Topics

Images & Videos

Know how unlike humans some organisms like naked mole rats, rock fish, lobsters, and bristlecone pines can pause their aging process

Know how telomeres protect the ends of the chromosomes and over a while, it causes cellular aging

For Students

aging summary

Read Next

A human Inuit skull in a stone chambered cairn in Ilulissat in Greenland. These ancient graves are pre christian and are at least 2000

14 Tough Questions Answered

Discover

Four year old boy with grandfather and father lighting Hanukkah menorah. Photo taken on: December 21st, 2009

Which Is Correct: Hanukkah or Chanukah?

Ahura Mazda - relief of the Zoroastrian god Ahura Mazda at the ancient ruins of Persepolis in Iran. Also known as Ormazd Zoroastrianism,

Which Religion Is the Oldest?

Ice Sledge Hockey, Hockey Canada Cup, USA (left) vs Canada, 2009. UBC Thunderbird Arena, Vancouver, BC, competition site for Olympic ice hockey and Paralympic ice sledge hockey. Vancouver 2010 Olympic and Paralympic Winter Games, Vancouver Olympics

10 Best Hockey Players of All Time

What's the Difference Between a Solstice and an Equinox?

Timeline and Map of the Panama Canal

Stylish light blue jeans on wooden background, closeup of inset pocket

Why Do Jeans Have That Tiny Pocket?

The Jeff Koons tulips sculputure outside the Guggenheim Museums in Bilbao, Spain, Basque Country.

What’s the Difference Between Modern and Contemporary Art?

Other theories of aging focus attention on factors that can influence the expression of a genetically determined “program.” These theories all attempt to explain aging in terms of cellular and molecular changes. Actually, age changes are much more marked in the overall performance of an individual than in cellular processes that can be measured. The age decrement in the ability to perform muscular work is much greater than any changes that can be detected in the enzyme activities of the muscles that perform the work. It is possible that aging in an individual is actually due to a breakdown in ...(100 of 9184 words)

Access the full article

Help support true facts by becoming a member.