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Also known as: gene transfer therapy, genetic modification
Written by
John Harris
Sir David Alliance Professor of Bioethics, University of Manchester. His contributions to SAGE Publications's Encyclopedia of Disability (2006) formed the basis of his contributions to Britannica.
John Harris,
Anthony J.F. Griffiths
Professor Emeritus of Botany, University of British Columbia, Vancouver. Coauthor of An Introduction to Genetic Analysis and others.
Anthony J.F. Griffiths•All
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Encyclopaedia Britannica's editors oversee subject areas in which they have extensive knowledge, whether from years of experience gained by working on that content or via study for an advanced degree. They write new content and verify and edit content received from contributors.
The Editors of Encyclopaedia Britannica
Last Updated: • Article History
Also called:
gene transfer therapy
Key People:
Fred H. Gage

News •

New gene therapy reverses heart failure in large animal model • Dec. 11, 2024, 12:14 AM ET (Medical Xpress)
A sickle cell first: Base editing, a new form of gene therapy, leaves patient feeling 'more than fine' • Dec. 8, 2024, 4:28 AM ET (Medical Xpress)
A universal gene therapy for Diamond-Blackfan anemia is poised for clinical trials • Nov. 26, 2024, 4:27 AM ET (Medical Xpress)

gene therapy, introduction of a normal gene into an individual’s genome in order to repair a mutation that causes a genetic disease. When a normal gene is inserted into the nucleus of a mutant cell, the gene most likely will integrate into a chromosomal site different from the defective allele; although that may repair the mutation, a new mutation may result if the normal gene integrates into another functional gene. If the normal gene replaces the mutant allele, there is a chance that the transformed cells will proliferate and produce enough normal gene product for the entire body to be ...(100 of 712 words)

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