human leukocyte antigen
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- Cell Press - Cancer Cell - The human leukocyte antigen as a candidate tumor suppressor
- Academia - Basics of Human Leukocyte Antigen (HLA) System and Its Application in Clinical Specialties
- National Center for Biotechnology Information - Biochemistry, HLA Antigens
- Genetic Home Reference - Human leukocyte antigens
- BMC - BMC Oral Health - What the Paris 1924 olympics tell us about promoting oral health for community sport - a call to action
- MSD Manual Professional Edition - Human Leukocyte Antigen (HLA) System
- Frontiers - Frontiers in Immunology - Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections?
- Verywell Health - HLA Typing: Purpose, Genetics, Procedure, Interpretation
human leukocyte antigen (HLA), any of the numerous antigens (substances capable of stimulating an immune response) involved in the major histocompatibility complex (MHC) in humans. The HLA genes encode the cell-surface proteins that are part of the MHC.
HLA antigens are programmed by a highly variable gene complex consisting of more than 200 genes, all of which occur on chromosome 6. HLA genes are divided into three distinct groups: class I, class II, and class III. The possibility of numerous variations in these genes serves a key role in providing the immune system with the ability to defend against a wide range of antigens.
The HLA system is useful in tissue typing, in which tissues from one individual are analyzed to determine whether they can be successfully transplanted to another individual. A number of HLA genes are associated with human diseases, including certain autoimmune disorders and cancer.