toxoplasmosis
- Key People:
- Albert Bruce Sabin
toxoplasmosis, infection of cells of the central nervous system, spleen, liver, and other organs by a parasite, Toxoplasma gondii. Infection occurs in domestic and wild animals, birds, and humans and is worldwide in distribution. It is estimated that 30 to 50 percent of the world’s human population carries demonstrable antibodies (indicating previous exposure), but overt symptoms are rare in adults. Swollen glands and fever are the most common findings in those who have any symptoms.
Organisms of the genus Toxoplasma reproduce by fission or internal budding. They move by a gliding motion, lacking either flagella or pseudopodia. They are classified in the family Sarcocystidae, which contains organisms known to have complex life histories; in the case of T. gondii, this centres on its ability to switch from a proliferative stage to a dormant stage, with the formation of latent tissue cysts that allow the organism to persist in the host.
There are several ways in which T. gondii can be transmitted. These include congenital transmission, passed from a pregnant woman to a fetus through the placenta; foodborne transmission, such as via consumption of undercooked contaminated meat; zoonotic transmission, from accidental ingestion of oocysts, which can occur after handling contaminated soil or cat litter; and, rarely, transmission by blood transfusion or organ transplantation. Toxoplasmosis acquired during pregnancy may result in stillbirth, miscarriage, or spontaneous abortion; infected infants may show various symptoms including jaundice, encephalitis, mental defects, and eye disease. Siblings of an infected infant are usually normal.
