vitamin K
- Key People:
- Edward Adelbert Doisy
- Henrik Dam
- Related Topics:
- human nutrition
- vitamin
- vitamin K deficiency
vitamin K, any of several fat-soluble naphthoquinone compounds. Vitamin K (from the Danish word koagulation) is required for the synthesis of several blood clotting factors, including prothrombin and factors VII, IX, and X. A form of vitamin K known as phylloquinone (vitamin K1) is synthesized by plants. A second form of vitamin K known as menaquinone (vitamin K2) is synthesized by bacteria, including bacteria in the intestines of mammals. These bacteria produce the majority of vitamin K that mammals require. A synthetic vitamin K precursor called menadione (vitamin K3) is used as a vitamin supplement. First recognized in 1929, the vitamin was isolated and analyzed structurally in 1939 by Danish biochemist Henrik Dam.
A deficiency of vitamin K in the body leads to an increase in clotting time of the blood. Vitamin K deficiency is seldom naturally encountered in higher animals because the vitamin is usually adequately supplied in the diet, besides being synthesized by intestinal bacteria. In humans, deficiency may occur following the administration of certain drugs that inhibit the growth of the vitamin-synthesizing bacteria or as a result of disorders affecting the production or flow of bile, which itself is necessary for the intestinal absorption of vitamin K. In newborn infants, the absence of intestinal bacteria, low levels of vitamin K in the mother’s milk, or the absence of body stores of vitamin K may result in bleeding, which can be prevented by the administration of vitamin K to the infant shortly after birth. (See table of the vitamins.)
| vitamin | alternative names/forms | biological function | symptoms of deficiency |
|---|---|---|---|
| Water-soluble | |||
| thiamin | vitamin B1 | component of a coenzyme in carbohydrate metabolism; supports normal nerve function | impairment of the nerves and heart muscle wasting |
| riboflavin | vitamin B2 | component of coenzymes required for energy production and lipid, vitamin, mineral, and drug metabolism; antioxidant | inflammation of the skin, tongue, and lips; ocular disturbances; nervous symptoms |
| niacin | nicotinic acid, nicotinamide | component of coenzymes used broadly in cellular metabolism, oxidation of fuel molecules, and fatty acid and steroid synthesis | skin lesions, gastrointestinal disturbances, nervous symptoms |
| vitamin B6 | pyridoxine, pyridoxal, pyridoxamine | component of coenzymes in metabolism of amino acids and other nitrogen-containing compounds; synthesis of hemoglobin, neurotransmitters; regulation of blood glucose levels | dermatitis, mental depression, confusion, convulsions, anemia |
| folic acid | folate, folacin, pteroylglutamic acid | component of coenzymes in DNA synthesis, metabolism of amino acids; required for cell division, maturation of red blood cells | impaired formation of red blood cells, weakness, irritability, headache, palpitations, inflammation of mouth, neural tube defects in fetus |
| vitamin B12 | cobalamin, cyanocobalamin | cofactor for enzymes in metabolism of amino acids (including folic acid) and fatty acids; required for new cell synthesis, normal blood formation, and neurological function | smoothness of the tongue, gastrointestinal disturbances, nervous symptoms |
| pantothenic acid | as component of coenzyme A, essential for metabolism of carbohydrate, protein, and fat; cofactor for elongation of fatty acids | weakness, gastrointestinal disturbances, nervous symptoms, fatigue, sleep disturbances, restlessness, nausea | |
| biotin | cofactor in carbohydrate, fatty acid, and amino acid metabolism | dermatitis, hair loss, conjunctivitis, neurological symptoms | |
| vitamin C | ascorbic acid | antioxidant; synthesis of collagen, carnitine, amino acids, and hormones; immune function; enhances absorption of non-heme iron (from plant foods) | swollen and bleeding gums, soreness and stiffness of the joints and lower extremities, bleeding under the skin and in deep tissues, slow wound healing, anemia |
| Fat-soluble | |||
| vitamin A | retinol, retinal, retinoic acid, beta-carotene (plant version) | normal vision, integrity of epithelial cells (mucous membranes and skin), reproduction, embryonic development, growth, immune response | ocular disturbances leading to blindness, growth retardation, dry skin, diarrhea, vulnerability to infection |
| vitamin D | calciferol, calatriol (1,25-dihydroxy vitamin D1 or vitamin D hormone), cholecalciferol (D3; plant version), ergocalciferol (D2; animal version) | maintenance of blood calcium and phosphorus levels, proper mineralization of bones | defective bone growth in children, soft bones in adults |
| vitamin E | alpha-tocopherol, tocopherol, tocotrienol | antioxidant; interruption of free radical chain reactions; protection of polyunsaturated fatty acids, cell membranes | peripheral neuropathy, breakdown of red blood cells |
| vitamin K | phylloquinone, menaquinone, menadione, naphthoquinone | synthesis of proteins involved in blood coagulation and bone metabolism | impaired clotting of the blood and internal bleeding |