lipid
- Related Topics:
- steroid
- isoprenoid
- prostaglandin
- lipoprotein
- phospholipid
- On the Web:
- Mustansiriyah University - Lipid definition , classification , chemistry, and metabolism (Dec. 09, 2024)
What is a lipid?
Why are lipids important?
What are lipid rafts?
lipid, any of a diverse group of organic compounds including fats, oils, hormones, and certain components of membranes that are grouped together because they do not interact appreciably with water. One type of lipid, the triglycerides, is sequestered as fat in adipose cells, which serve as the energy-storage depot for organisms and also provide thermal insulation. Some lipids such as steroid hormones serve as chemical messengers between cells, tissues, and organs, and others communicate signals between biochemical systems within a single cell. The membranes of cells and organelles (structures within cells) are microscopically thin structures formed from two layers of phospholipid molecules. Membranes function to separate individual cells from their environments and to compartmentalize the cell interior into structures that carry out special functions. So important is this compartmentalizing function that membranes, and the lipids that form them, must have been essential to the origin of life itself.
Water is the biological milieu—the substance that makes life possible—and almost all the molecular components of living cells, whether they be found in animals, plants, or microorganisms, are soluble in water. Molecules such as proteins, nucleic acids, and carbohydrates have an affinity for water and are called hydrophilic (“water-loving”). Lipids, however, are hydrophobic (“water-fearing”). Some lipids are amphipathic—part of their structure is hydrophilic and another part, usually a larger section, is hydrophobic. Amphipathic lipids exhibit a unique behavior in water: they spontaneously form ordered molecular aggregates, with their hydrophilic ends on the outside, in contact with the water, and their hydrophobic parts on the inside, shielded from the water. This property is key to their role as the fundamental components of cellular and organelle membranes.
Although biological lipids are not large macromolecular polymers (e.g., proteins, nucleic acids, and polysaccharides), many are formed by the chemical linking of several small constituent molecules. Many of these molecular building blocks are similar, or homologous, in structure. The homologies allow lipids to be classified into a few major groups: fatty acids, fatty acid derivatives, cholesterol and its derivatives, and lipoproteins. This article covers the major groups and explains how these molecules function as energy-storage molecules, chemical messengers, and structural components of cells.
Fatty acids
Fatty acids rarely occur as free molecules in nature but are usually found as components of many complex lipid molecules such as fats (energy-storage compounds) and phospholipids (the primary lipid components of cellular membranes). This section describes the structure and physical and chemical properties of fatty acids. It also explains how living organisms obtain fatty acids, both from their diets and through metabolic breakdown of stored fats.
Structure
Biological fatty acids, members of the class of compounds known as carboxylic acids, are composed of a hydrocarbon chain with one terminal carboxyl group (COOH). The fragment of a carboxylic acid not including the hydroxyl (OH) group is called an acyl group. Under physiological conditions in water, this acidic group usually has lost a hydrogen ion (H+) to form a negatively charged carboxylate group (COO−). Most biological fatty acids contain an even number of carbon atoms because the biosynthetic pathway common to all organisms involves chemically linking two-carbon units together (although relatively small amounts of odd-number fatty acids do occur in some organisms). Although the molecule as a whole is water-insoluble by virtue of its hydrophobic hydrocarbon chain, the negatively charged carboxylate is hydrophilic. This common form for biological lipids—one that contains well-separated hydrophobic and hydrophilic parts—is called amphipathic.
In addition to straight-chain hydrocarbons, fatty acids may also contain pairs of carbons linked by one or more double bonds, methyl branches, or a three-carbon cyclopropane ring near the centre of the carbon chain.