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superoxide dismutase
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superoxide dismutase

enzyme

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role in amyotrophic lateral sclerosis

  • In amyotrophic lateral sclerosis: Causes of ALS

    …enzyme known as SOD, or superoxide dismutase, appear to facilitate the destruction of motor neurons by harmful molecules known as free radicals (molecular by-products of normal cell metabolism that can accumulate in and destroy cells). ALS-associated mutations in SOD1 result in the inability of the SOD enzyme to neutralize free…

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  • Barr body
    In human genetic disease: Molecular oxygen

    …from mutations affecting the enzyme superoxide dismutase. The disease is genetically dominant, so that the mutant enzyme causes the disease even when half of the superoxide dismutase present in cells exists in the normal form. Interestingly, most of the mutant variants retain full catalytic activity.

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